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One of the major breakthroughs in understanding the role of gut permeability in health and disease has been the discovery of zonulin, the only physiologic intestinal permeability modulator described so far 15, 16. Zonulin acts as a molecular gatekeeper, modulating the tight junctions between epithelial cells that line the intestinal wall. Zonulin is revolutionizing our ability to understand gut permeability and how it impacts a range of health conditions — from cancer to autoimmune disease to inflammation and food sensitivities.

Leaky gut syndrome occurs when the lining of the small intestine becomes disrupted, allowing potentially harmful substances to enter the bloodstream and causing a variety of negative symptoms It is predominantly found and produced in the cells of the small intestine Several leaky gut tests exist, but none is clinically validated

Of the existing tests, zonulin testing is popular in functional medicine

Increased zonulin levels correlate with health and disease and. A leaky gut, or intestinal permeability, occurs when the gut lining becomes too porous, allowing harmful substances to enter the bloodstream Zonulin is a key protein regulating this permeability Elevated zonulin levels can indicate compromised gut barrier function, which may contribute.

The immune system will start to produce specific antibodies against zonulin, and these can be accurately measured by the lab Discover how zonulin affects gut permeability, leaky gut, and autoimmune disease—and learn proven ways to lower it naturally through diet and lifestyle. Increased zonulin is a hallmark of untreated celiac disease, but is seen in other disorders, especially autoimmune disorders in general. Learn how a little known protein called zonulin can sometimes play a role in a healthy gut and the state of the microbiome.

Zonulin is a protein that appears to be a main cause of the holes created in the tight junctions of the intestines

Zonulin is released from harmful bacteria in the gut as well as from gliadin Zonulin is a protein that plays a crucial role in the regulation of intestinal permeability, also known as the leaky gut phenomenon

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